Wednesday, February 29, 2012

The Emperor of All Maladies

3 In the 1950s, people were terrified of cancer and did not want to talk about let alone face them. The New York Times refused to print the word “cancer” or “breast” for advertisement of cancer support-group. People have been terrified of cancer even though heart disease kills more people than cancer. In 1958, Science Digest reported that there were 450,000 new cases of cancer diagnosed each year and seven hundred thousand cases of cancer were being treated in America. In 1958, according to Patterns of Disease, one woman in four under the age of thirty-five could expect to get cancer, and one in seven would die from it; one man in five under the age of fifty would be afflicted, and one in eight would die. People tend to connect cancer to death immediately because cancers come out again and again after the doctors treated them. It is like the dead people come out again from the grave and eat people’s lives. I think that people’s feeling towards cancer and zombies are same. In 1950s, many doctors believed that cancer was not curable. Now people started to believe that cancer is curable. However, cancer’s nature of proliferation and invasion of nearby tissue in the body still scares people. Today, doctors and scientists believe that cancer is a genetic disease. For instance BRCA 1 and BRCA 2 genes cause breast cancer. In the future, people go to the oncologist’s clinic to check cancer genome for early prevention of these dreadful diseases.

4 Sidney Farber used anti-folate for leukemia treatment in 1947. Dr. Faber utilized folate analogues, which are chemical compounds that should reduce the growth of leukemia cells, and he tested his anti-folates on leukemia patients. It was a new treatment and first used by Sidney Farber to treat acute childhood leukemia. This finding encouraged other researchers to discover drugs that blocked different functions involved in cell growth and replication. This is the era of chemotherapy history. Siddhartha Mukherjee explains, “cancer as not one but many diseases.”

Sidney Farber devoted his life to save his cancer patients. He predicted that folic acid antagonists would inhibit or stop the proliferation of cancer cells. His research was used to find other chemotherapeutic agents. Under his influence and leadership, he founded the “Jimmy Fund”, which was one of the first comprehensive pediatric oncology treatment center, and the Children’s Cancer Research Foundation. Later this foundation became the Dana-Farber Cancer Institute.

5

Min Chiu Li was accused of using his patients for his experiments. He was not an American, but Chinese. So he was called an outsider. I feel that there are some cultural differences between Chinese and American. American people tend to put value about people’s feelings. Chiu Li had been studying cancer, therefore he knew the nature of recurrent cancer and he could recognize the sign of life for them. He cared about numbers and obsessed over the number “0” in order to reach an hcg level of 0. Therefore, he continued to treat chemotherapy drugs long after the patient looked well. It looked cold and heartless to care more about numbers for some doctors. I understand them because chemotherapy is horrible toxins to the body. Min Chiu Li lost his job for that, but he turned out to be right. Any trace of cancer was detected by indicators such as hcg level, where cancer relapsed some months later. What is worse, this relapse becomes more resistant to chemotherapy. When I had herpies because of stress, some American people believes that HIV causes these diseases. In Japan, it is very common in hihgly stressed people. I had to do many tests to prove that I did not have HIV. When I took medication, one doctor told me that if I took excess of drugs, I didn’t have any side-effects of disease like headache. I did not want to have a headache, so I took excess of medicines to fight back to this virus even through this doctor was reluctant to give me excess medications because of ethical issues. As a result, I am headache free my entire my life. So many people complain headache after this disease. Sometimes we need to take a risk to fight back against diseases. It is very difficult to deal with human bodies because we have exceptionally complicated bodies.

The Emperor of All Maladies

Friday, December 23, 2011

Monday, December 12, 2011

The Immortal Life of Henrietta Lacks

I cant begin to rant on how much I enjoyed this book. Before reading this book I had never heard the name HeLa and I’m astounded because of how much of a contribution to science these cells were. They are fundamental to many of the vaccines produced, ethics legislation and science in general. HIV,HPV,Polio are just few of many examples of diseases that were studied using HeLa cells, for all of these diseases there has been tremendous advancements that I don’t believe could have been possible without HeLa cells. However, I wonder where would science be if they did have federal laws like HIPAA. It doesn’t seem like the cells would have been patented like they were and distributed on a world wide scale like they were. I do believe that a large part of their success was due to their availability and the fact that they were from such a unique tumor that it could be exposed to so many different studies. It is horrible what did happen to the Lacks family and how they lived in poverty so long while these major companies made millions from their discoveries that perhaps were not possible without HeLa cells. What is even more saddening about this book is how for so long Henrietta Lacks was unknown and didn’t receive the credit she deserved for her amazing contributions to science. Where would science be without HeLa cells? Therefore, where would science be without Henrietta Lacks?

HeLa's contributions to the Nobel Prize

Zur Hausen won a Nobel Prize using HeLa cells to create a HPV vaccine. Richard Axel went on to win the Nobel Prize by infecting HeLa cells with HIV. Of these discoveries using HeLa cells the most significant, in my opinion, is that of the enzyme telomerase. This explained the mechanics of HeLa’s immortality because telomerase renews the end of Hela’s chromosomes so they never grew old and never died.

Today: Nobel Prize Awarded for Telomerase Discovery, and the 58th Anniversary of Henrietta Lacks's Death Category: HeLa History of Science and Medicine News The Immortal Life of Henrietta Lacks Women and Science Posted on: October 5, 2009 11:58 AM, by Rebecca Skloot

It's fitting that today -- the day after the 58th anniversary ofHenrietta Lacks's death -- the Nobel Prize in medicine has been awarded toElizabeth Blackburn, Carol Greider, and Jack Szostak for the discovery of how telomeres and the enzyme telomeraseprotect chromosomes from degrading over time. In the late eighties, a scientist at Yale used Henrietta's cells (aka HeLa, pictured left) to discover that human cancer cells contain telomerase, which regenerates their chromosomes and prevents them from aging and dying like normal cells. This is one of the reasons why Henrietta's cells are still alive and growing today, fifty-eight years after her death.



3 Americans Share Nobel for Medicine

Associated Press, European Pressphoto Agency, Associated Press

From left, Jack Szostak, Carol Greider and Elizabeth Blackburn.

Published: October 5, 2009

The Nobel Prize in Physiology or Medicine was awarded Monday to three American scientists who solved a problem of cell biology with deep relevance to cancer and aging. The three will receive equal shares of a prize worth around $1.4 million.

Related

Psychiatrist Is Among Five Chosen for Medical Award(September 17, 2006)

A Conversation With Elizabeth H. Blackburn: Finding Clues to Aging in the Fraying Tips of Chromosomes (July 3, 2007)

New Glimpses of Life’s Puzzling Origins (June 16, 2009)

Times Topics: Nobel Prizes

Nobel Prize Announcements

More on the Medicine Laureates(nobelprize.org)

Schedule for Nobel Prizes Announcements

Physics: Tuesday, October 6, 5:45 AM ET

Chemistry: Wednesday, October 7, 5:45 AM ET

Literature: Thursday, October 8, 7:00 AM ET

Peace: Friday, October 9, 5:00 AM ET

Economics: Monday, October 12, 7:00 AM ET

RSS Feed

The recipients solved a longstanding puzzle involving the ends of chromosomes, the giant molecules of DNA that embody the genetic information. These ends, calledtelomeres, get shorter each time a cell divides and so serve as a kind of clock that counts off the cell’s allotted span of life.

The three winners are Elizabeth H. Blackburn of theUniversity of California, San Francisco; Carol W. Greider of the Johns Hopkins University School of Medicine; and Jack W. Szostak of Massachusetts General Hospital.

The discoveries were made some 20 years ago in pursuit of a purely scientific problem that seemingly had no practical relevance. But telomeres have turned out to play a role in two medical areas of vast importance, those of aging and cancer, because of their role in limiting the number of times a cell can divide.

“I am thrilled that the basic science can be celebrated,” Dr. Greider said in an interview Monday.

Only eight women had won the Nobel Prize in Physiology or Medicine. Asked how she felt about becoming No. 9, Dr. Blackburn replied, “Very excited, and hoping that nine will quickly become a larger number.”

Thomas Cech, a Nobel Prize winner at the University of Colorado, said the discovery had had a broad impact on several fields of biology and medicine and had also provided a “fascinating insight” into the transition between the DNA world and the RNA world that preceded it in the origin of life. RNA is a close chemical cousin of DNA.

Though Americans have again made a clean sweep of the Nobel medicine prize, two of the three winners are immigrants. Dr. Blackburn was born in Tasmania, Australia, and has dual citizenship; Dr. Szostak was born in London. Dr. Blackburn came to the United States in the 1970s because it was “notably attractive” as a place to do science. While America is still a magnet for foreign scientists, she said, “one shouldn’t take that for granted.”

Dr. Szostak also said the world was now more competitive in science. “So maybe we have to work a little harder to attract people from around the world and make sure they stay here,” he said.

Dr. Cech, former president of the Howard Hughes Medical Institute, said the more onerous visa requirements imposed on foreign scientists in the wake of the Sept. 11 attacks were benefiting European countries especially. “Even now, there is an implication when foreign scientists apply for visas that they should be distrusted, denied several times, and should have to hire lawyers and jump through a lot of hoops,” he said.

All three of the prize winners seem to have had science in their genes, and certainly in their home environment. Dr. Greider is the daughter of two scientists with doctorates from the University of California, Berkeley, and she, too, has a Ph.D. from there. Dr. Szostak’s father was an engineer. Both of Dr. Blackburn’s parents were physicians.

The study of telomeres is notable as a field of research in which female scientists are particularly prominent. Dr. Greider said she ascribed this to a “founder effect,” the founder being Joseph Gall of Yale University. Dr. Gall trained Dr. Blackburn and other women, and they recruited others to the field “because there is a slight tendency for women to work with other women,” Dr. Greider said. She herself trained with Dr. Blackburn.

The field of telomere research grew out of a puzzle in the mechanics of copying DNA. The copying enzyme works in such a way that one of the two strands of the double helix is left a little shorter after each division. Work by the three winners and others led to the discovery of telomerase, a special enzyme that can prevent the shortening by adding extra pieces of DNA.

Dr. Blackburn addressed this problem by working with a single-cell organism found in pond water known as Tetrahymena. She found in 1978 that the telomeres had a very unusual structure, in which the same sequence of six DNA units was repeated some 50 times.

She and Dr. Szostak, who with her help had detected telomeres in yeast, then proposed that cells must possess a special enzyme that added these repeat units to the end of chromosomes so as to compensate for the incomplete job done by the copying enzyme.

Working in Dr. Blackburn’s lab as a graduate student, Dr. Greider tracked down this enzyme, now known as telomerase, in a central experiment that finished on Christmas Day, 1984. Going into the lab that morning, Dr. Greider saw from the telltale signature of the six-unit repeat that she had captured telomerase. “That was a really exciting day,” she said.

Later she found that telomerase contains a special piece of RNA that it uses as a template to elongate the chromosome with the six-unit repeats. The unexpected involvement of RNA reflects a time early in the origin of life when all the important chores in the cell were performed by RNA, not DNA.

This piece of basic biology soon turned out to have important implications for aging and cancer. Telomerase is usually active only at the beginning of life; thereafter the telomeres get shorter each time a cell divides. If they get too short, a cell is thrown into senescence, meaning that it cannot divide again.

Short telomeres are known to have a role in certain diseases of aging, like aplastic anemia. Telomeres are also important in cancer, a disease in which control of cell proliferation is lost. Cancer cells need to reactivate the telomerase gene, or their telomeres will get steadily shorter, forcing them into senescence. In some 80 to 90 percent of human cancer cells, the telomerase gene has been switched back on, Dr. Blackburn said. The Geron Corporation has two clinical trials under way, one of a drug and one of a vaccine, to see whether cancers can be treated by inhibiting telomerase.

Both Dr. Blackburn and Dr. Greider still work on telomerase, but Dr. Szostak left the field 20 years ago to explore a much broader question: how life could have originated from the simple chemicals present on the early earth. He has already made advances in this long intractable field, notably by showing how a proto-cell could have formed and then imported the RNA building blocks. Dr. Szostak hopes next to show how the proto-cell and its RNA could divide naturally into two daughter cells, a feat that, if achieved, could well be a candidate for a second Nobel Prize.

Right to Privacy

One very interesting point I found in the book was that deceased have no right to privacy even if a part of them is still alive, this was the justification for every doctor that dealt with Henreitta‘s medial records, pictures or her cells. Under the 1996 HIPAA act a patient's privacy rights survive death and last forever. However, this is still violated even to this day. The fallowing link is about a young girl who crashed her car and pictures of her mangled body were spread all over the internet. Even though this was in clear violation of HIPAA California courts ruled in favor of the internet sites saying that the deceased did not have any privacy rights because they do not continue after death. Because HIPAA is a federal law how were the courts able to rule in favor of the internet sites? How was this justified? Its astonishing that the same issues/violations in the book are still present today. It seems like there will always be violations of patients rights even with federal laws in effect.

http://www.cbsnews.com/video/watch/?id=5018327n